Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress
نویسندگان
چکیده
BACKGROUND This study examined the effects of Palm vitamin E (PVE) and α-tocopherol (α-TF) supplementations on adrenalin, noradrenalin, xanthine oxidase plus dehydrogenase (XO + XD) activities and gastric lesions in rats exposed to water-immersion restraint stress (WIRS). METHODS Sixty male Sprague-Dawley rats (200-250 g) were randomly divided into three equal sized groups. The control group was given a normal diet, while the treated groups received the same diet with oral supplementation of PVE or α-TF at 60 mg/kg body weight. After the treatment period of 28 days, each group was further subdivided into two groups with 10 rats without exposing them to stress and the other 10 rats were subjected to WIRS for 3.5 hours. Blood samples were taken to measure the adrenalin and noradrenalin levels. The rats were then sacrificed following which the stomach was excised and opened along the greater curvature and examined for lesions and XO + XD activities. RESULTS The rats exposed to WIRS had lesions in their stomach mucosa. Our findings showed that dietary supplementations of PVE and α-TF were able to reduce gastric lesions significantly in comparison to the stressed control group. WIRS increased plasma adrenalin and noradrenalin significantly. PVE and α-TF treatments reduced these parameters significantly compared to the stressed control. CONCLUSIONS Supplementations with either PVE or α-TF reduce the formation of gastric lesions. Their protective effect was related to their abilities to inhibit stress induced elevation of adrenalin and noradrenalin levels as well as through reduction in xanthine oxidase and dehydrogenase activities.
منابع مشابه
PALM VITAMIN E REDUCES CATECHOLAMINES, XANTHINE OXIDASE ACTIVITY AND GASTRIC LESIONS IN RATS EXPOSED TO WATER-IMMERSION RESTRAINT STRESS Running Title: PALM VITAMIN E: EFFECTS ON CATECHOLAMINES, LIPID PEROXIDATION AND GASTRIC LESIONS IN STRESS RATS
متن کامل
Palm tocotrienol-rich fraction supplementation suppressed stress-induced gastric oxidative stress in rats
Palm tocotrienol-rich fraction (TRF), an extract from palm oil containing both tocotrienol and tocopherol, is known for its antioxidant effect. The present study investigated the effect of palm TRF on the stomach using a water immersion restraint stress (WRS) model. Fortytwo male Sprague-Dawley rats were divided into three groups and were administered 60 mg/kg/d of palm TRF, α-tocopherol or veh...
متن کاملThe effects of palm vitamin E on stress hormone levels and gastric lesions in stress-induced rats
INTRODUCTION This study examines the effects of palm vitamin E (PVE) or α-tocopherol (α-TF) supplementation on adrenocorticotropin hormone (ACTH), corticosterone and gastric lesions in rats exposed to water-immersion restraint stress (WIRS). MATERIAL AND METHODS Sixty male Sprague-Dawley rats (200-250 g) were divided into three groups. Group I: 20 rats as a control group were given a normal d...
متن کاملBiol. Pharm. Bull. 28(8) 1424—1430 (2005)
clinically used for the treatment of gastric ulcers and gastritis. Takagi and Yano reported that when gefarnate was orally administered to fasted rats for 5 d, the level of hexosamine, an index of gastric mucus, in the pyloric tissue of the stomach increased and that the reduction of hexosamine content in the gastric pyloric tissue of rats with 3 d of water immersion restraint stress (WIRS) was...
متن کاملProtective Effect of Repeatedly Preadministered Brazilian Propolis Ethanol Extract against Stress-Induced Gastric Mucosal Lesions in Rats
The present study was conducted to clarify the protective effect of Brazilian propolis ethanol extract (BPEE) against stress-induced gastric mucosal lesions in rats. The protective effect of BPEE against gastric mucosal lesions in male Wistar rats exposed to water-immersion restraint stress (WIRS) for 6 h was compared between its repeated preadministration (50 mg/kg/day, 7 days) and its single ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2012